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Identification of a specific sperm nuclei selenoenzyme necessary for protamine thiol cross-linking during sperm maturation

Nature 377 : 115118

10.1038/304111a0 Nature 44 CzikkM

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17beta-estradiol ameliorates lipotoxicity-induced hepatic mitochondrial oxidative stress and insulin resistance

Epigenetic modifications, including hypomethylation of ER and aromatase promoters, further sustain this estrogen-driven phenotype, with endocrine-disrupting chemicals (EDCs) such as dioxins and phthalates potentially exacerbating these epigenetic alterations ( Progesterone resistance, characterized by impaired progesterone receptor (PR) signaling despite bioavailable progesterone, perpetuates ectopic lesion survival and contributes to infertility ( The interplay of estrogen dominance and progesterone resistance disrupts endometrial homeostasis, directly impacting fertility